| Date | Home |
Away |
|
| 03.09.05 | Otley | 16-16 | Bedford |
| 10.09.05 | Bedford | 47-17 | Doncaster |
| 17.09.05 | Bedford | 34-13 | Sedgley Park |
| 24.09.05 | London Welsh | 24-40 | Bedford |
| 01.10.05 | Bedford | 31-12 | Cornish Pirates |
| 08.10.05 | Bedford | 24-16 | Rotherham |
| 22.10.05 | Nottingham | 10-25 | Bedford |
| 29.10.05 | Bedford | 35-18 | Birmingham/Solihull |
| 05.11.05 | Bedford | 61-0 | Blackheath |
| 19.11.05 | Plymouth | 28-23 | Bedford |
| 26.11.05 | Bedford | 57-17 | Esher |
| 03.12.05 | Bedford | 20-26 | Harlequins |
| 10.12.05 | Newbury | 17-50 | Bedford |
| 17.12.05 | Bedford | 28-13 | Exeter |
| 26.12.05 | Coventry | 24-31 | Bedford |
| 01.01.06 | Bedford | 42-20 | Otley |
| 08.01.06 | Otley | 13-14 | Bedford |
| 14.01.06 | Doncaster | 17-24 | Bedford |
| 21.01.06 | Sedgley Park | 29-45 | Bedford |
| 28.01.06 | Bedford | 38-17 | London Welsh |
| 12.02.06 | Cornish Pirates | 26-21 | Bedford |
| 18.02.06 | Rotherham | 9-31 | Bedford |
| 25.02.06 | Bedford | 21-26 | Nottingham |
| 04.03.06 | Exeter | 35-37 | Bedford |
| 11.03.06 | Birmingham/Solihull | 16-68 | Bedford |
| 25.03.06 | Bedford | 34-28 | Plymouth |
| 01.04.06 | Exeter | 26-23 | Bedford |
| 09.04.06 | Bedford | 23-39 | Harlequins |
| 15.04.06 | Bedford | 40-27 | Coventry |
| 22.04.06 | Harlequins | 45-36 | Bedford |
| 29.04.06 | Bedford | 79-22 | Newbury |